A close examination of Kim's argument in "Multiple Realization and the Metaphysics of Reduction" for the claim that if a kind is multiply realizable in a way that blocks identification with more fundamental properties it is also a kind unlikely to appear as an appropriate kind in a theory in the first place. Ultimately, I argue that there is one reasonably promising argument of this sort, but its success turns on explanatory questions the answers to which are far from obvious.

Reparations whether to blacks for slavery, or to Indians for land theft, or to settle any number of other conflicts, has an interesting political background. Analysts on the left, who are usually no friend of private property rights, nevertheless rely on this doctrine to support their case for reparations. Those on the right, in contrast, who supposedly defend the institution of property rights, jettison them when it comes to reparations. It is only libertarians, such as the present authors, who both (...) favor private property rights in general, and, also, apply them to the issue of reparations, who are logically consistent. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with (...) rice of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

The human genome is not a uniform structure but, instead, is a mosaic of bands. Some of these bands can be seen by the eye. Stained with Giemsa and viewed under the microscope each human chromosome has a prototypical pattern of light and dark bands (G and R bands respectively). Other bands are not so easily viewed. The human genome is, for example, a mosaic of isochores, blocks of DNA within which the proportion of the bases G and C at (...) silent sites (introns, third positions in codons, intergene spacer) is fairly uniform. Recent work by Matassi and colleagues(1) has revealed what might be a new and unexpected banding pattern. They have found that the genes which are close together on the chromosome have similar rates of evolution. BioEssays 22:105–107, 2000. ©2000 John Wiley & Sons, Inc. (shrink)

The protein tyrosine kinase activity of the v‐abl oncogene has been demonstrated to subvert the normal second messenger systems used by lymphoid cells for growth and differentiation. Transformation of bone marrow with the Abelson murine leukemia virus results in the appearance of B cell lineage cells arrested at the pre‐B cell stage. Recent reports have characterized these cells expressing high v‐abl kinase activity as deficient in detectable NF‐kB DNA binding activity and low level RAG gene expression. These observations suggest (...) that v‐abl may be inhibiting the differentiation of B cells by blocking these two crucial elements in the maturation pathway. (shrink)

DNA methylation is a quintessential epigenetic mechanism. Widely considered a stable regulator of gene silencing, it represents a form of “molecular braille,” chemically printed on DNA to regulate its structure and the expression of genetic information. However, there was a time when methyl groups simply existed in cells, mysteriously speckled across the cytosine building blocks of DNA. Why was the code of life chemically modified, apparently by “no accident of enzyme action” (Wyatt 1951 )? If all cells in a (...) body share the same genome sequence, how do they adopt unique functions and maintain stable developmental states? Do cells remember? In this historical perspective, I review epigenetic history and principles and the tools, key scientists, and concepts that brought us the synthesis and discovery of prokaryotic and eukaryotic methylated DNA. Drawing heavily on Gerard Wyatt’s observation of asymmetric levels of methylated DNA across species, as well as to a pair of visionary 1975 DNA methylation papers, 5-methylcytosine is connected to DNA methylating enzymes in bacteria, the maintenance of stable cellular states over development, and to the regulation of gene expression through protein-DNA binding. These works have not only shaped our views on heritability and gene regulation but also remind us that core epigenetic concepts emerged from the intrinsic requirement for epigenetic mechanisms to exist. Driven by observations across prokaryotic and eukaryotic worlds, epigenetic systems function to access and interpret genetic information across all forms of life. Collectively, these works offer many guiding principles for our epigenetic understanding for today, and for the next generation of epigenetic inquiry in a postgenomics world. (shrink)

The apolipoprotein E gene plays an important role in the pathogenesis of Alzheimer's disease , and amyloid plaque comprised mostly of the amyloid-beta peptide ) is one of the major hallmarks of AD. However, the relationship between these two important molecules is poorly understood. We examined how A treatment affects APOE expression in cultured cells and tested the role of the transcription factor NF-B in APOE gene regulation. To delineate NF-B's role, we have characterized a 1098 nucleotide segment (...) containing the 5'-flanking region of the human APOE gene . Sequence analysis of this region suggests the presence of two potential NF-B elements. To demonstrate promoter activity, the region was cloned upstream of a promoterless luciferase gene. This segment was able to drive expression of luciferase in transient transfections of human fetal glial cells. Promoter activity was stimulated twofold by A treatment. Pretreatment with double-stranded DNA decoy oligonucleotides against NF-B reduced A stimulation. Deletion and mutagenetic analyses demonstrated that the distal NF-B element was functional and showed a strong DNA-protein complex band in gel shift analysis, similar to that from control NF-B consensus element. An anti-inflammatory and anti-NF-B drug, sodium salicylate, significantly blocked A-induced APOE promoter function. Our data provide evidence that upregulation of APOE by A in astroglial cells is mediated by an NF-B-element present in the 5'-flanking region of the APOE gene. (shrink)

Discussion of partial grounds that aren't parts of full grounds; definition of full grounding in terms of partial grounding.

Defense of an account of intrinsic properties in terms of (what is now called) grounding rather than naturalness.

How should the “physical” in “physicalism” be understood? I here set out systematic criteria of adequacy, propose an account, and show how the account meets those criteria. The criteria of adequacy focus on the idea of rational management: to vindicate philosophical practice, the account must make it plausible that we can assess various questions about physicalism. The account on offer is dubbed the “Ideal Naturalist Physics” account, according to which the physical is that which appears in an ideal theory that (...) both meets the explanatory goals of physics and is naturalist in a sense to be explained. The combination of these two provides a satisfying account of the physical that meets the criteria of adequacy and can be used to predict puzzle cases as well. (shrink)

What has come to be known as “a priori physicalism” is the thesis, roughly, that the non-physical truths in the actual world can be deduced a priori from a complete physical description of the actual world. To many contemporary philosophers, a priori physicalism seems extremely implausible. In this paper I distinguish two kinds of a priori physicalism. One sort – strict a priori physicalism – I reject as both unmotivated and implausible. The other sort – liberal a priori physicalism – (...) I argue is both motivated and plausible. This variety of a priori physicalism insists that the necessitation of non-physical truths by the physical facts must be underwritten in a certain fashion by a priori knowledge, but the a priori knowledge need not amount to a simple deduction of the non-physical truths from a complete physical description of the world. Further, this sort of liberal a priori physicalism has the advantage that it offers hope for a genuinely satisfying account of how the physical facts manage to necessitate the facts about phenomenal consciousness – thereby in effect solving the “hard problem” of consciousness. The first half of the paper sets out the motivation for liberal a priori physicalism and its superiority to the strict version; the second half presents one strategy available to the liberal a priori physicalist for showing how consciousness can be accommodated in a purely physical world. (shrink)

Evolutionary psychology and human sociobiology often reject the mere possibility of symbolic causality. Conversely, theories in which symbolic causality plays a central role tend to be both anti-nativist and anti-evolutionary. This article sketches how these apparent scientific rivals can be reconciled in the study of disgust. First, we argue that there are no good philosophical or evolutionary reasons to assume that symbolic causality is impossible. Then, we examine to what extent symbolic causality can be part of the theoretical toolbox of (...) the evolutionary social sciences. This examination leads to the conclusion that it is possible to make evolutionary sense of Mary Douglas’s theory of disgust, and that her view of symbolic causality can and should inform evolutionary theories of (sociocultural) disgust. (shrink)

Recent work by Jaegwon Kim and others suggest that functionalism leaves mental properties causally inefficacious in some sense. I examine three lines of argument for this conclusion. The first appeals to Occam's Razor; the second appeals to a ban on overdetermination; and the third charges that the kind of response I favor to these arguments forces me to give up "the homogeneity of mental and physical causation". I show how each argument fails. While I concede that a positive theory of (...) mental causation is desirable, there is no reason to think that functionalism renders such a theory unattainable. (shrink)

This slim volume is sure to provoke. The topics include physicalism, the theory of color, and metaethics, but the primary focus is metaphilosophical: Jackson aims to defend the use of conceptual analysis as a tool for doing “serious metaphysics.”.

A substantial guide providing an overview of both physicalism and metaphysical naturalism, reviewing both questions of formulation and justification for both doctrines. Includes a diagnostic strategy for understanding talk of naturalism as a metaphysical thesis.

In his book Intuition, Elijah Chudnoff develops an account of how we might, by having intuitions, be made aware of abstract objects. While the conditions under which we enjoy such awareness are, on his account, happily free of objectionable metaphysics or dubious mechanisms, it is not clear that the conditions bear the epistemic weight they need to carry. To flesh out this worry, I develop an example that is parallel in all relevant respects to cases of intuitive awareness as described (...) by Chudnoff but in which the subject lacks awareness. This paper is a descendant of remarks delivered at the 2014 conference of the Florida Philosophical Association during a book symposium on Elijah Chudnoff’s Intuition. (shrink)

The manifestability argument presented by Papineau and Loewer turns on the premise that nonphysical properties are capable of making a difference to physical conditions. From this and the completeness of physics a strenuous supervenience conclusion is supposed to follow. I argue that the plausible version of this premise implies a weaker supervenience thesis only, one that is too weak to be of any use for a physicalist. There is a more contentious premise one might use to deduce the needed conclusion, (...) but that more contentious premise has no empirical support. (shrink)

What has become known asthe blockers problemis an alleged difficulty facing attempts to formulate physicalism as a supervenience thesis. A blocker is an entity, itself contrary to physicalism, with the power to disrupt an otherwise necessary connection between physical and nonphysical conditions. I argue that there is no distinct blockers problem. Insofar as a problem can be identified, it turns out to be just a rather baroque version of a distinct and familiar objection to supervenience formulations and to be of (...) no independent interest. Work on the formulation of physicalism can thus proceed without worrying about blockers. (shrink)

In his Consciousness and Fundamental Reality (2017) Philip Goff defends his anti-physicalist argument against what he calls the "Dual Carving" objection—the idea that two representations of the very same fact could both be conceptually independent and "transparent," that is, revealing of the essences of the entities in question. His defense invokes a thesis he calls "Minimal Rationalism." I explore exactly how Minimal Rationalism is supposed to turn aside the objection and argue that the formulation of Minimal Rationalism on offer is (...) ambiguous between stronger and weaker readings. Goff needs the stronger reading to use it in defense of his argument, but only the weaker reading is warranted by the considerations he brings to bear in favor of his rationalism. His minimal rationalism is, in sum, insufficiently minimal. The upshot is not only that Goff is deprived of a way of turning back an important objection to his case against physicalism; we also gain a better sense of what kind of rationalist thesis is properly invoked in metaphysics. (shrink)

In his 'The Disorder of Things' John Dupré presents an objection to reductionism which I call the 'anti-essentialist objection': it is that reductionism requires essentialism, and essentialism is false. I unpack the objection and assess its cogency. Once the objection is clearly in view, it is likely to appeal to those who think conceptual analysis a bankrupt project. I offer on behalf of the reductionist two strategies for responding, one which seeks to rehabilitate conceptual analysis and one (more concessive) which (...) avoids commitment to any such analysis. (shrink)

Charles Siewert has given us an ingenious thought experiment involving a limited lack of conscious experience. The possibility of the described case is incompatible with a number of popular theories of consciousness. Siewert acknowledges, however, that this possibility is not a direct threat to "hidden feature" theories. I aim to do two things: first, strengthen his defense of the claim that the case is genuinely possible by considering and rejecting some further attempts to explain away our temptation to believe it (...) possible; and second, to explore how a hidden feature approach could be developed and made plausible. (shrink)

Presidential Address for the 2011 meeting of the Florida Philosophical Association. A somewhat playful but also serious meditation on ways in which the philosophical impulse can be understood as an urge to demystify or render "boring." Topics include psychological peculiarities of philosophers, reflections on methods for teaching students at an introductory level, the contrast between science and philosophy, the sense in which philosophy may or may not begin in "wonder," and why we should value the process of taking the magic (...) out of everything, ending with the declaration that it’s good to make everything boring—at least, in the specific sense here delineated. (shrink)

Early last year, the GenEthics Consortium (GEC) of the Washington Metropolitan Area convened at George Washington University to consider a complex case about genetic testing for Alzheimer disease (AD). The GEC consists of scientists, bioethicists, lawyers, genetic counselors, and consumers from a variety of institutions and affiliations. Four of the 8 co-authors of this paper delivered presentations on the case. Supplemented by additional ethical and legal observations, these presentations form the basis for the following discussion.

Based on brain imaging findings, we present a model according to which addiction emerges as an imbalance in the information processing and integration among various brain circuits and functions. The dysfunctions reflect (a) decreased sensitivity of reward circuits, (b) enhanced sensitivity of memory circuits to conditioned expectations to drugs and drug cues, stress reactivity, and (c) negative mood, and a weakened control circuit. Although initial experimentation with a drug of abuse is largely a voluntary behavior, continued drug use can eventually (...) impair neuronal circuits in the brain that are involved in free will, turning drug use into an automatic compulsive behavior. The ability of addictive drugs to co‐opt neurotransmitter signals between neurons (including dopamine, glutamate, and GABA) modifies the function of different neuronal circuits, which begin to falter at different stages of an addiction trajectory. Upon exposure to the drug, drug cues or stress this results in unrestrained hyperactivation of the motivation/drive circuit that results in the compulsive drug intake that characterizes addiction. (shrink)

Stalking the elusive physicalist thesis Content Type Journal Article Pages 1-5 DOI 10.1007/s11016-011-9528-2 Authors D. Gene Witmer, Department of Philosophy, University of Florida, P. O. Box 118545, Gainesville, FL 32611-8545, USA Journal Metascience Online ISSN 1467-9981 Print ISSN 0815-0796.